For a full report see Geerts 2009 "Of Mice and Men: Bridging the translational disconnect in CNS R&D".
| Parameter ||Animal models||ISB Computational Platform|
|Drug Affinities||Clinical candidate is often optimized for rodent target subtypes||Accounts for possible differences because use of human target affinities|
|Neurotransmitter Circuits||Differently wiring (receptor distributions) in rodents can limit predictivity||Uses human circuits & distributions|
|Drug Exposure||Rodents metabolize faster and different active metabolites can be formed||Can use exposure and unique meatbolites from human patients|
|Functional Genotypes||Specific human genotypes often impossible to recreate in rodent models||Where imaging information available is incorporated into platform|
|Polypharmacy||Very expensive and difficult to perform in preclinical models||Approved psycho-active medications (antidepressants, anti-convulsants, sleep-medication and antipsychotics) part of the platform.|
|Complete Human Pathology||Difficult to get complete pathology in rodent model||Uses complete pathology from imaging and postmortem studies|
Return to Technology.