Limitation of Animal Models


The top-down computer simulation of complex CNS pathological processes in psychiatric and neurological disorders, based upon signal processing between different brain regions is a new form of quantitative systems pharmacology. The physiology of different CNS targets covering all major neuromodulators from dopamine to glutamate is implemented and the pathology is introduced as changes on different neurotransmitter systems in patients using imaging and post-mortem data.

General overview of the modeling strategy. We make the existing computational neuroscience expertise actionable for CNS R&D by introducing neuromodulatory physiology, the pharmacology of CNS active compounds and the human pathology.