Publications Archive - In Silico Biosciences

Conceptual and organizational barriers to quantitative systems pharmacology modeling of pathophysiological systemic drug hypotheses

Ronald Gieschke, Robert Carr

November 7, 2022

CPT: Pharmacometrics & Systems Pharmacology

The future of Parkinson’s disease research: A new paradigm of human-specific investigation is necessary… and possible

Manuela Cassotta, Hugo Geerts, Lise Harbom, Tiago F. Outeiro, Iosif Pediaditakis, Orly Reiner, Stefan Schildknecht, Jens C. Schwamborn, Jarrod Bailey, Kathrin Herrmann, Helena T. Hogberg

October 18, 2022

ALTEX

A quantitative systems pharmacology model for simulating OFF-Time in augmentation trials for Parkinson’s disease: application to preladenant

Rachel Rose, Emma Mitchell, Piet Van Der Graaf, Daisuke Takaichi, Jun Hosogi, Hugo Geerts

October 9, 2022

Journal of Pharmacokinetics and Pharmacodynamics

Toward Predicting Impact of Common Genetic Variants on Schizophrenia Clinical Responses With Antipsychotics: A Quantitative System Pharmacology Study

Athan Spiros and Hugo Geerts

September 29, 2021

Frontiers in Neuroscience

Quantitative systems pharmacology in neuroscience: Novel methodologies and technologies

Peter Bloomingdale, Tatiana Karelina, Murat Cirit, Sarah F. Muldoon, Justin Baker, William J. McCarty, Hugo Geerts, Sreeraj Macha

May 1, 2021

CPT: Pharmacometrics & Systems Pharmacology

Re-engineering CNS drug discovery and development using computer aided modeling

Hugo Geerts

November 23, 2020

In Silico Pharmacology

Using dynamic clamp to quantify pathological changes in the excitability of primary somatosensory neurons

Petri Takkala and Steven A. Prescott

June 1, 2018

The Journal of Physiology

Impact of amyloid-beta changes on cognitive outcomes in Alzheimer’s disease: analysis of clinical trials using a quantitative systems pharmacology model

Hugo Geerts, Athan Spiros, Patrick Roberts

February 2, 2018

Alzheimer's Research & Therapy

Combined Changes in Chloride Regulation and Neuronal Excitability Enable Primary Afferent Depolarization to Elicit Spiking without Compromising its Inhibitory Effects

Petri Takkala, Yi Zhu, Steven A. Prescott

November 11, 2016

PLOS Computational Biology

Phenotypic screening of the Prestwick library for treatment of Parkinson’s tremor symptoms using a humanized quantitative systems pharmacology platform.

Athan Spiros, Patrick Roberts, Hugo Geerts

June 1, 2013

Journal of Parkinson's Disease

Publications